Apparently, it has been shown by scientists that delivering blood from a young mouse to an old mouse or vice versa prompts an effect of Freaky Friday. As the vitality is lose by the brains of the young mice unprotected to the old blood, while some brain function is rejuvenated by the young blood in the elder mice. However, what they aren’t aware of is what makes these transformations happen. Recently, it was reported by the scientists that they had locked on to a protein made by the blood vessels as a main player in knowing how elder blood appears to encourage cellular impairment in the brain.
Additionally, it was too found by them that disabling the protein improved the function of their brain cells in grown-up mice and the performance of the mice on cognitive tests. The research was printed in the Nature Medicine journal, directs to the protein, known as VGAM1, as a probable target for a treatment for neurocognitive syndromes. The brain cells are called to be as microglia, as both mice and human get older, which is kind of immune cell of the nervous system, develop extra active, creating neuroinflammation.
Simultaneously, the neural stem cell’s activity involved in developing more neurons gets compressed down. Altogether, these changes are considered to play a chief role in the functional and structural deterioration, which occurs as we age. These similar cellular responses to elderly are triggered by inserting blood from a grown-up mouse to an undeveloped mouse, signifying that definite factors in the plasma indicate for these variations to occur. But a healthy brain is sealed off from the blood unlike other organs by a barrier, parting the question unanswered of how the blood components might influence what is exactly happening inside the brain.